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Nutritional Intervention For
Optimizing Mitochondrial Performance

Anta Badulescu, Kamilia Talipova, Shuk Yee Ngan, and Frank Merante

45 million adults in North America exercise to improve health and sport specific conditioning. There is also high demand for nutritional products which support improved aerobic capacity, and post exercise recovery. The problem is many of the most widely used nutritional products provide marginal benefits .

Mitronite is interested in safe, effective, and evidence based nutritional interventions that are proven to support improved energy by providing nutritional compounds required by the cellular systems of the body.

We collaborated with the Seneca College School of Biological Sciences and Applied Chemistry on an in vivo kinesiology testing model to demonstrate the performance enhancement characteristics of Mitronite, in athletes.

Background

Physical and mental exertion places a demand on cellular metabolic reserves. By providing key metabolic intermediates to the cellular mitochondria before, during, and after training, optimal cellular homeostasis and metabolic replenishing molecules are provided, enabling optimal recovery of cellular reserves and aerobic cellular function.

The purpose of this study was to investigate and determine if the exercise work capacity and recovery, can be improved through the administration of a synergistic blend of metabolic nutrients key, which includes Vitamin C and metabolic intermediates: Citrate, Malate and Pyruvate.

Methods

A total of 14 participants volunteered to complete 2 training sessions; a control session (“un-dosed”)  and a ”dosed” session. Three different exercises of 10 sets each, were included in the two sessions. There was a 20 second work set followed by a  90 seconds rest.

The Number of repetitions, the repetition in which onset of burn began, and peak burn severity were recorded. In addition, sweat samples were collected to detect and analyze metabolites, minerals, other trace elements (data not shown). 

Results

Exercise Work Capacity (EWC) in un-dosed (without Mitronite) vs. dosed (with Mitronite) conditions was analyzed from three different perspectives. EWC as represented by:

  1. The number of reps completed,
  2. The rep at which athletes experienced the onset of exercise induced muscle burn (Onset of Burn), and 
  3. The Peak Burn Severity (PBS) experienced by athletes at the conclusion of each work set.

The results indicated that the nutritional intervention created a significant positive impact on Exercise Work Capacity.

This project was funded by Project funded by Seneca’s Applied Research Fund (ARF).

Mean change in number of reps completed increased by 1.16 ± .23 in the dosed condition vs. the undosed condition. Significantly different (p<0.01).  Undosed mean 11.77, SD is 4.67; SEM (shown on figure) is 0.07.  Mean reps com…

Mean change in number of reps completed increased by 1.16 ± .23 in the dosed condition vs. the undosed condition. Significantly different (p<0.01).  Undosed mean 11.77, SD is 4.67; SEM (shown on figure) is 0.07.  Mean reps completed in the dosed condition were 12.93, SD 4.98; SEM (show on figure) is 0.07.  

Mean change in the onset of exercise induced muscle burn increased by 1.41 ±.31 (95% confidence interval, z=1.96) in the dosed condition vs. the undosed condition. Significantly different (p&lt;0.01).&nbsp;&nbsp;Undosed mean of reps completed withou…


Mean change in the onset of exercise induced muscle burn increased by 1.41 ±.31 (95% confidence interval, z=1.96) in the dosed condition vs. the undosed condition. Significantly different (p<0.01).  Undosed mean of reps completed without burn 8.25, SD (Excel stdev.p) is 5.10; SEM (shown on figure) is 0.09.  Mean of reps completed without burn in the dosed condition was 9.67, SD 5.37; SEM (show on figure) is 0.08.  

Mean change in reported Peak Burn Severity (PBS) of Exercise Induced Muscle Burn decreased by 0.44 ±&nbsp;.09 in the dosed condition vs. the undosed condition. Significantly different (p&lt;0.01).&nbsp;&nbsp;Undosed mean 2.90, SD is 1.15 (Excel stde…

Mean change in reported Peak Burn Severity (PBS) of Exercise Induced Muscle Burn decreased by 0.44 ± .09 in the dosed condition vs. the undosed condition. Significantly different (p<0.01).  Undosed mean 2.90, SD is 1.15 (Excel stdev.p); SEM (shown on figure) is 0.03. Dosed mean 2.46, SD 1.13 (Excel stdev.p); SEM (shown on figure) is 0.04. 

Mitronite provides Primary Metabolic Energy Nutrients.  

These nutrients are used to produce energy and improve mitochondrial function.

 

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